LGP2 plays extensive roles in modulating innate immune responses in Ctenopharyngodon idella kidney (CIK) cells. Issue 1 (March 2015)

• Record Type: Journal Article
• Authors: Chen, Xiaohui; Yang, Chunrong; Su, Jianguo; Rao, Youliang; Gu, Tianle
• Is Part Of: Developmental and comparative immunology. Volume 49:Issue 1(2015)
• Page Start: 138
• Page End: 148
• Publication Date: 2015-03
• Subjects: Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2014.10.012
• Languages: English
• ISSNs: 0145-305X

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Overexpression of <italic>CiLGP2</italic> induced <italic>CiRIG-I</italic> but inhibited <italic>CiIPS-1</italic> expression in CIK cells.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015"> <italic>CiLGP2</italic> cooperated with <italic>CiMDA5</italic> to enhance antiviral signaling against GCRV.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020"> <italic>CiLGP2</italic> impaired RLR-dependent antiviral responses to poly(I:C).</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025"> <italic>CiLGP2</italic> altered the expression patterns of RLR genes after LPS treatment.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030"> <italic>CiLGP2</italic> significantly enhanced the RLR signaling upon PGN stimulation.</p> </list-item> </list> </p> </sec> </abstract>