Control of systemic proteostasis by the nervous system. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Mardones, Pablo; Martínez, Gabriela; Hetz, Claudio
• Is Part Of: Trends in cell biology. Volume 25:Issue 1(2015)
• Page Start: 1
• Page End: 10
• Publication Date: 2015-01
• Subjects: Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2014.08.001
• Languages: English
• ISSNs: 0962-8924

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The proteostasis network mediates cellular adaptation to protein-folding stress.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Cell-nonautonomous regulation of peripheral proteostasis is controlled by the central nervous system.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Cell-nonautonomous control of proteostasis is implicated in thermoregulation, innate immunity, energy balance, and aging.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Targeting the regulation of proteostasis by the nervous system has therapeutic potential.</p> </list-item> </list> </p> </sec> </abstract>