Advances in our structural understanding of orphan nuclear receptors. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Gallastegui, Nerea; Mackinnon, Jonathan A.G.; Fletterick, Robert J.; Estébanez-Perpiñá, Eva
• Is Part Of: Trends in biochemical sciences. Volume 40:Issue 1(2015)
• Page Start: 25
• Page End: 35
• Publication Date: 2015-01
• Subjects: Biochemistry -- Periodicals; 572
• DOI: 10.1016/j.tibs.2014.11.002
• Languages: English
• ISSNs: 0968-0004

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0025">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">More than half of human nuclear receptors (NRs) lack characterized natural ligands.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Structural characterization has led to the discovery of unexpected ligands.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Structural studies increased our understanding of NR selectivity and specificity.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Many NRs are ligand independent, questioning canonical regulatory mechanisms.</p> </list-item> <list-item id="lsti0025"> <label> <italic></italic> </label> <p id="par0025">Understanding interdomain communication is a challenging but advancing area.</p> </list-item> </list> </p> </sec> </abstract>