Risk of venous thromboembolism occurrence among adults with selected autoimmune diseases: A study among a U.S. cohort of commercial insurance enrollees. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Yusuf, Hussain R.; Hooper, W. Craig; Grosse, Scott D.; Parker, Christopher S.; Boulet, Sheree L.; Ortel, Thomas L.
• Is Part Of: Thrombosis research. Volume 135:Issue 1(2015)
• Page Start: 50
• Page End: 57
• Publication Date: 2015-01
• Subjects: Thrombosis -- Periodicals; 616.135
• DOI: 10.1016/j.thromres.2014.10.012
• Languages: English
• ISSNs: 0049-3848

Abstract

<abstract abstract-type="author" id="ab0005"> <title id="st0005">Abstract</title> <sec> <title id="st0010">Objective</title> <p id="sp0005">This study assessed the risk of venous thromboembolism (VTE) among privately insured adults in the U.S. with one or more of the following autoimmune diseases: autoimmune hemolytic anemia (AIHA), immune thrombocytopenic purpura (ITP), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE).</p> </sec> <sec> <title id="st0015">Materials and Methods</title> <p id="sp0010">Using the Truven Health MarketScan® Databases, patients 18–64 years of age with a diagnosis of AIHA, ITP, RA, or SLE in 2007 and a sex and age-group matched comparison group of enrollees were followed up through 2010 to identify VTE events. Survival curve and Cox proportional hazards analyses were conducted to assess differences between groups.</p> </sec> <sec> <title id="st0020">Results</title> <p id="sp0015">Among patients with AIHA, ITP, RA, or SLE, or > 1 of these diseases, the risk of at least one VTE event was 19.74, 7.72, 4.90, 9.89, and 13.35 per 1, 000 person-years, respectively; among the comparison group, the risk was 1.91 per 1, 000 person-years. The adjusted hazard ratios (aHRs) for VTE among patients with AIHA, ITP, RA, or SLE, or > 1 of these diseases (when compared with the comparison group) tended to decline over follow-up time; at 1 year, the aHRs were 6.30 (95% confidence interval [CI]: 4.44–8.94), 2.95 (95% CI: 2.18–4.00), 2.13 (95% CI: 1.89–2.40), 4.68 (95% CI: 4.10–5.33), and 5.11 (95% CI: 4.26–6.14), respectively.</p> </sec> <sec> <title id="st0025">Conclusion</title> <p id="sp0020">Having AIHA, ITP, RA, or SLE, or > 1 of these diseases was associated with an increased likelihood of a VTE event. More research is necessary to develop better understanding of VTE occurrence among people with autoimmune diseases.</p> </sec> </abstract>