Prevalence, incidence and predictors of anal high-risk HPV infections and cytological abnormalities in HIV-infected individuals. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Borghetti, Alberto; Cattani, Paola; Maria, Giorgio; D'Onghia, Sara; Santangelo, Rosaria; Marchetti, Simona; Farina, Salvatore; Cauda, Roberto; De Luca, Andrea; Di Giambenedetto, Simona
• Is Part Of: Journal of infection. Volume 70:Issue 1(2015)
• Page Start: 60
• Page End: 71
• Publication Date: 2015-01
• Subjects: Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2014.07.025
• Languages: English
• ISSNs: 0163-4453

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Summary</title> <sec> <title id="sectitle0015">Objectives</title> <p id="abspara0010">Our purpose was to investigate prevalence, incidence and risk factors of anal high risk-HPV infections and cytological abnormalities in HIV-positive individuals.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">A cohort of consecutively enrolled HIV-positive patients underwent, at baseline visit, a sexual behaviors questionnaire, anoscopy, HPV testing and cytological examination. Hybridization and multiplex-PCR were used for DNA detection and typing; HPV E6-E7 mRNA expression was analyzed in HR-HPV+ patients. Logistic regression was used to assess predictors of HR-HPV infection and anal dysplasia.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">233 HIV-infected patients were enrolled (81% males, median age 44 years). HR-HPV was detected in 144 anal swabs and showed a positive association with CDC stage C and a negative association with a higher CD4 count and the use of a NNRTI-based antiretroviral regimen. HR-HPV DNA detection and anal warts at baseline were associated to cytological abnormalities; a detectable HIV-RNA independently predicted new onset anal dysplasia at follow-up (incidence 15.4 per 100 patients-year). Incidence of new HR-HPV infection was 44.2 per 100 patients-year.</p> </sec> <sec> <title id="sectitle0030">Conclusions</title> <p id="abspara0025">The relevance of screening for anal dysplasia in HIV+ patients is emphasized, especially in those with detectable plasma HIV-RNA, anal HR-HPV infection or compromised immunological status.</p> </sec> </abstract>