Age-related hair changes in men: Mechanisms and management of alopecia and graying. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Mirmirani, Paradi
• Is Part Of: Maturitas. Volume 80:Issue 1(2015:Jan.)
• Page Start: 58
• Page End: 62
• Publication Date: 2015-01
• Subjects: Climacteric -- Periodicals; Menopause -- Periodicals; Climacteric -- Periodicals; Geriatrics -- Periodicals; Menopause -- Periodicals; Middle Aged -- Periodicals; Climatère -- Périodiques; Ménopause -- Périodiques; Climacterium; Climacteric; Menopause; Electronic journals; Periodicals; 612.66
• DOI: 10.1016/j.maturitas.2014.10.008
• Languages: English
• ISSNs: 0378-5122

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Androgenetic alopecia and senescent alopecia are the two main causes of thinning in men.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">In androgenetic alopecia, hormonal signals lead to changes in genes regulating hair follicle size and cycling and there is a gradual diminution of the hair follicle.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">In senescent alopecia, which has its onset after the age of 60, follicular dropout and thinning occur as a results of apoptosis and oxidative stress responses and may be a manifestation of systemic aging processes.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Extrinsic factors such as hair processing, ultraviolet light, and smoking have a deleterious effect on the hair.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Hair graying may reflect a decreased ability to handle oxidative damage as well as loss of follicular melanocytes and melanin content.</p> </list-item> </list> </p> </sec> </abstract>