Prevalence of BRCA-1 associated protein 1 germline mutation in sporadic malignant pleural mesothelioma cases. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Rusch, Andreas; Ziltener, Gabriela; Nackaerts, Kristiaan; Weder, Walter; Stahel, Rolf A.; Felley-Bosco, Emanuela
• Is Part Of: Lung cancer. Volume 87:Issue 1(2015:Jan.)
• Page Start: 77
• Page End: 79
• Publication Date: 2015-01
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2014.10.017
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Genetic alterations in the BAP1 gene have been identified in 23% of MPM specimens.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Germline BAP1 mutations have been detected in families with a high incidence of MPM.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The frequency germlines mutations in MPM sporadic patients, has not been thoroughly investigated.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">We present the largest screening to date of germline BAP1 mutation in sporadic MPM patients.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">One out of 78 patients showed a germline synonymous mutation in exon 11.</p> </list-item> </list> </p> </sec> </abstract>