Oral contraception does not alter typical post-exercise interleukin-6 and hepcidin levels in females. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Sim, Marc; Dawson, Brian; Landers, Grant; Swinkels, Dorine W.; Tjalsma, Harold; Yeap, Bu B.; Trinder, Debbie; Peeling, Peter
• Is Part Of: Journal of science and medicine in sport. Volume 18:Issue 1(2015:Jan.)
• Page Start: 8
• Page End: 12
• Publication Date: 2015-01
• Subjects: Sports sciences -- Periodicals; Sports medicine -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports -- physiology -- Periodicals; Sports Medicine -- Periodicals; Sportgeneeskunde; 617.102705
• DOI: 10.1016/j.jsams.2013.11.008
• Languages: English
• ISSNs: 1440-2440

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Objectives</title> <p id="spar0005">The post-exercise interleukin-6 (IL-6) and hepcidin response was investigated during the hormone-deplete and hormone-replete phases of an estradiol and progestogen regulated oral contraceptive cycle (OCC).</p> </sec> <sec> <title id="sect0015">Design</title> <p id="spar0040">Counterbalanced, repeated measures cross-over study.</p> </sec> <sec> <title id="sect0020">Methods</title> <p id="spar0010">Ten active female monophasic oral contraceptive pill (OCP) users completed two 40 min treadmill running trials at 75% of their pre-determined peak oxygen uptake velocity (vVO<sub>2peak</sub>). These trials were randomly performed in two specific phases of the OCC: (a) Day 2–4, representing a hormone-free withdrawal period (D − 0); (b) Day 12–14, representing the end of the first week of active hormone therapy (D + 7). Venous blood samples were drawn pre-, post- and 3 h post-exercise.</p> </sec> <sec> <title id="sect0025">Results</title> <p id="spar0015">In both trials, serum IL-6 was significantly elevated (<italic>p</italic> < 0.05) immediately post-exercise, while serum hepcidin was significantly elevated (<italic>p</italic> < 0.05) 3 h post-exercise, with no significant differences recorded between trials.</p> </sec> <sec> <title id="sect0030">Conclusions</title> <p id="spar0020">These findings suggest that exercise performed during the different phases (D − 0 vs. D + 7) of a monophasic OCP regulated cycle does not alter exercise induced IL-6 or hepcidin production. As such, future studies looking to investigate similar variables post-exercise, may not need to 'control' for different phases of the OCC, provided participants are current monophasic OCP users.</p> </sec> </abstract>