10. Prediction of good and poor outcome in comatose patients after cardiac arrest: The utility of early EEG/SEP recordings during therapeutic hypothermia. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Amantini, A.; Carrai, R.; Spalletti, M.; Comanducci, A.; Cossu, C.; Gabbanini, S.; Peris, A.; Gensini, G.F.; Grippo, A.
• Is Part Of: Clinical neurophysiology. Volume 126:Issue 1(2015:Jan.)
• Page Start: e3
• Publication Date: 2015-01
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2014.10.029
• Languages: English
• ISSNs: 1388-2457

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="sp005">To evaluate the prognostic value of EEG and SEPs in post-anoxic comatose patients at 12 h, 24 h and 72 h from cardiac arrest (CA). Comatose patients after CA treated with TH were included. EEG and SEPs were recorded within 12 h, 24 h and 72 h after CA. EEG was classified into "non-continuous" (low voltage, isoelectric, burst-suppression) and "continuous" (other patterns except epileptiform). SEPs were dichotomized into "bilaterally absent" (BA) and "present". Neurologic outcome was evaluated at 6 months by GOS: "awakening" (GOS 3–5) was considered good outcome. EEG and SEPs were recorded in 147 patients, 33 of whom within 12 h. "Continuous" EEG pattern at 12 h always predicted good outcome, "non-continuous" pattern at 72 h always predicted poor outcome. BA SEPs always predicted poor outcome. Early "continuous" EEG pattern was always associated with present SEPs. SEPs provide a specific and time-independent predictor of poor outcome (bilateral absence). EEG provide a specific and time-dependent predictor of good outcome ("continuous" pattern at &lt;12 h) and poor outcome ("non-continuous" pattern at 48–72 h). Early "continuous" EEG and BA SEPs are never associated together. Combined EEG/SEPs recordings are a useful tool for reliable prognostication both of good and poor outcome in comatose patients treated with TH.</p> </sec> </abstract>