85. Deep repetitive transcranial magnetic stimulation with H-coil for motor symptoms in Parkinson's disease: A randomized, double blind, placebo-controlled study. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Fichera, M.; Spagnolo, F.; Chieffo, R.; Houdayer, E.; Coppi, E.; Nuara, A.; Di Maggio, G.; Ferrari, L.; Libera, D. Dalla; Velikova, S.; Bianco, M.; Straffi, L.; Zangen, A.; Comi, G.; Volontè, M.A.; Leocani, L.
• Is Part Of: Clinical neurophysiology. Volume 126:Issue 1(2015:Jan.)
• Page Start: e20
• Publication Date: 2015-01
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2014.10.104
• Languages: English
• ISSNs: 1388-2457

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="sp005">To evaluate the effect of repetitive deep transcranial magnetic stimulation—rDTMS on motor symptoms in Parkinson's Disease—PD in a randomized, placebo controlled study. Sixty patients underwent 12 sessions (3 sessions/week) of 10 Hz rDTMS, after randomization into 3 groups: Group 1 (real rDTMS on primary motor—M1 and prefrontal—PF areas); Group 2 (M1-real/PF-sham), Group 3 (M1-sham/PF-sham). Primary outcome was percent reduction of Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III, OFF therapy. Secondary outcomes were: changes in UPDRSIII sub-scores; improvement in timed tests (Hand Tapping—HT, Foot Tapping—FT, Walking Time—WT, Nine Hole Peg Test—NHPT). Statistical analysis was performed using Mann–Whitney or <italic>t</italic>-test. Outcomes were tested in hierarchical order, by comparing the two real groups (1–2) only if their pooled data significantly differed from sham. No drop-outs or serious adverse effects were recorded. Both real groups improved significantly more than sham in UPDRSIII (<italic>p</italic> = .010 and <italic>p</italic> = .045, respectively), while they did not significantly differ between them. Pooled real groups showed a significant improvement vs sham in UPDRSIII (<italic>p</italic> = .007), tremor (<italic>p</italic> = .011) and lateralized sub-scores (<italic>p</italic> = .042 and <italic>p</italic> = .012 for worse and better side, respectively). Timed tests significantly improved more in the real group vs sham on the worse side (HT <italic>p</italic> = .041, FT <italic>p</italic> = .012, NHPT <italic>p</italic> = .003). rDTMS with H-coil appeared safe and effective on motor symptoms as add-on treatment in PD.</p> </sec> </abstract>