5. Involvement of different cortico-subcortical circuits in chronic tinnitus: An Sloreta-based EEG study. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Houdayer, E.; Teggi, R.; Velikova, S.; Gonzalez-Rosa, J.J.; Bianco, M.; Trimarchi, M.; Bussi, M.; Comi, G.; Leocani, L.
• Is Part Of: Clinical neurophysiology. Volume 126:Issue 1(2015:Jan.)
• Page Start: e2
• Publication Date: 2015-01
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2014.10.024
• Languages: English
• ISSNs: 1388-2457

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="sp005">To assess the involvement of cortico-subcortical circuits in chronic, normoacoustic tinnitus sufferers using electroencephalography (EEG). 17 normoacoustic patients (6F, mean age 43.6 ± 9.8 y, disease duration 22 ± 35 months) presenting with chronic, unilateral high-pitched tinnitus were included, and compared to 17 controls. Subjects underwent resting-state EEG (29 electrodes, 5 min eyes opened, 5 min eyes closed) and an auditory oddball paradigm for even-related potentials (ERPs) analyses (N1, P2 and P300). Cortical distribution of current source density (CSD) of EEG data was computed with sLORETA. Eyes closed, patients had significantly decreased CSD of the alpha2 (10.5–12 Hz) rhythm in the left postcentral and inferior temporal gyri, and decreased gamma (30–100 Hz) CSD in the left temporal gyrus. Eyes opened, CSD of alpha2, beta2 (18.5–21 Hz), and gamma bands were decreased in patients over the inferior parietal lobule. Latency and amplitude of the P300 and P2 did not differ between groups. N1 latency was significantly shorter in patients.Our results suggest an impairment of cortico-thalamo-cortical circuits involving the auditory cortex in chronic tinnitus. Decreased alpha power is compatible with an increased activity of the postcentral and inferior temporal giri, and might reflect a maladaptive plasticity in chronic tinnitus.</p> </sec> </abstract>