95. Guillain–Barre syndrome: Comparison of neurophysiological standards parameters and validation of criteria for the diagnosis at an early stage. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Scarpino, M.; Carrai, R.; Canden, S.; Cossu, C.; Amantini, A.; Grippo, A.
• Is Part Of: Clinical neurophysiology. Volume 126:Issue 1(2015:Jan.)
• Page Start: e22
• Publication Date: 2015-01
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2014.10.114
• Languages: English
• ISSNs: 1388-2457

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="sp005">Electrodiagnostic criteria are of support to the diagnosis of GBS. Ho/Hadden (HH) criteria are the ones most commonly used although little specific. Dutch GBS Study Group (DGBSG) criteria seem to be the most sensitive and specific. Both, however, are not sensitive for early diagnosis of GBS. The aim of our study is to determine the more useful criteria in clinical practice and the utility of the proposed criteria for early diagnosis. Prospective study of patients admitted to AOU-Careggi with clinical suspicion of GBS. Clinical evaluation was based on Asbury criteria. Neurophysiological examination included standard nerves conduction, H-reflex, A-wave and distal CMAP duration. We recruited 20 patients, 1/3 met clinical criteria. HH criteria were positive in 4 patients, one of which had a diabetic polyneuropathy. DGBSG criteria were positive only in patients affected by GBS/CIDP. All the proposed criteria for early diagnosis resulted not specific for GBS. The most useful electrodiagnostic criteria are DGBSG. For early diagnosis, however, the standard criteria are not sensitive while the new ones are not specific. Therefore, diagnosis of GBS remains in first instance based on clinical examination. ENG should be performed only in patients meeting clinical criteria to increase level of diagnostic certainty.</p> </sec> </abstract>