32. Event-related potential correlates of word recognition memory in patients with coronary artery disease. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Giovannelli, F.; Simoni, D.; Baldasseroni, S.; Tarantini, F.; Pratesi, A.; Bartoli, N.; Foschini, A.; Giganti, F.; Cincotta, M.; Viggiano, M.P.
• Is Part Of: Clinical neurophysiology. Volume 126:Issue 1(2015:Jan.)
• Page Start: e8
• Publication Date: 2015-01
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2014.10.051
• Languages: English
• ISSNs: 1388-2457

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="sp005">The relationship between left ventricular ejection fraction (LVEF) and cognitive performance in patients with coronary artery disease (CAD) without overt heart failure is still under debate. In the present study we combine behavioural measures and event-related potentials (ERPs) to verify whether electrophysiological correlates of recognition memory (Old/New effect) is modulated differently as a function of LVEF. Twenty-five male patients with CAD (13 without [LVEF &gt; 55%] and 12 with [LVEF &lt; 40%] left ventricular dysfunction), and a Mini Mental State Examination score &gt; 25 were enrolled. ERPs were recorded while participants performed a visual word recognition task consisting of a test phase in which they were asked to judge whether visual stimuli were previously presented in a learning phase ('old') or not ('new'). ERPs responses from the test phase were analyzed. A late positive ERP component between 300 and 500 ms was differentially modulated in the two groups: a clear old/new effect (enhanced mean amplitude for old respect to new items) was observed in patients without LVEF dysfunction; whereas patients with overt LVEF dysfunction did not show such old/new effect. These data suggest that ERPs may reveal possible functional brain abnormalities that might be not observed at behavioural levels.</p> </sec> </abstract>