Contribution of human esterases to the metabolism of selected drugs of abuse. Issue 1 (5th January 2015)

• Record Type: Journal Article
• Authors: Meyer, Markus R.; Schütz, Aline; Maurer, Hans H.
• Is Part Of: Toxicology letters. Volume 232:Issue 1(2015)
• Page Start: 159
• Page End: 166
• Publication Date: 2015-01-05
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2014.10.026
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0035"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Characterization of the enzyme-catalyzed ester hydrolysis of ten drugs including eight drugs of abuse.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Investigation of different esterase sources and isoforms.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Kinetic parameters (<italic>V</italic>_max/<italic>K</italic>_m) determined for each reaction.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Presented data important for prediction of drug–drug or drug–food interactions as well as for individual variations in metabolism.</p> </list-item> </list> </p> </sec> </abstract>