Toxicological aspects of trans fat consumption over two sequential generations of rats: Oxidative damage and preference for amphetamine. Issue 1 (5th January 2015)

• Record Type: Journal Article
• Authors: Kuhn, Fábio Teixeira; Trevizol, Fabíola; Dias, Verônica Tironi; Barcelos, Raquel Cristine Silva; Pase, Camila Simonetti; Roversi, Karine; Antoniazzi, Caren Tatiane de David; Roversi, Katiane; Boufleur, Nardeli; Benvegnú, Dalila Moter; Emanuelli, Tatiana; Bürger, Marilise Escobar
• Is Part Of: Toxicology letters. Volume 232:Issue 1(2015)
• Page Start: 58
• Page End: 67
• Publication Date: 2015-01-05
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2014.10.001
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0065"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Rats received omega-3/-6 and trans fat (TF) from gestation over two generations.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Pups from 2nd generation were also supplemented until adolescence.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Omega-6 and TF groups showed higher anxiety and amphetamine (AMPH)-preference.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">TF group showed impairments in the antioxidant defense system in cortex/hippocampus.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Brain incorporation of trans/n-6 fatty acids may facilitate drug addiction.</p> </list-item> </list> </p> </sec> </abstract>