Induction of CD8+ T cell responses and protective efficacy following microneedle-mediated delivery of a live adenovirus-vectored malaria vaccine. Issue 28 (22nd June 2015)

• Record Type: Journal Article
• Authors: Pearson, Frances E.; O'Mahony, Conor; Moore, Anne C.; Hill, Adrian V.S.
• Is Part Of: Vaccine. Volume 33:Issue 28(2015)
• Page Start: 3248
• Page End: 3255
• Publication Date: 2015-06-22
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.03.039
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">A candidate malaria vaccine delivered using silicon microneedles was immunogenic.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Microneedle-induced T cell immunogenicity was equivalent to intradermal injection.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Vaccine responses correlated with the total array volume of the microneedle array.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Transgene expression after microneedle delivery also varied with total array volume.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Microneedle-primed ID-boosted responses were highly protective against challenge.</p> </list-item> </list> </p> </sec> </abstract>