Long term population impact of seven-valent pneumococcal conjugate vaccine with a "3 + 0″ schedule—How do "2 + 1″ and "3 + 1″ schedules compare?. Issue 28 (22nd June 2015)

• Record Type: Journal Article
• Authors: Lowbridge, Christopher; McIntyre, Peter B.; Gilmour, Robin; Chiu, Clayton; Seale, Holly; Ferson, Mark J.; Gilbert, Gwendolyn L.
• Is Part Of: Vaccine. Volume 33:Issue 28(2015)
• Page Start: 3234
• Page End: 3241
• Publication Date: 2015-06-22
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.04.079
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Introduction</title> <p id="spar0005">Significant reductions in invasive pneumococcal disease (IPD) following 7-valent pneumococcal conjugate vaccine (7vPCV) are well documented, but population-level data comparing different schedules are sparse. We compared data from long-term stable surveillance in one Australian region (3 primary doses (3 + 0) schedule) with similar data from England and Wales (2 + 1 schedule) and the United States (3 + 1 schedule).</p> </sec> <sec> <title id="sect0015">Methods</title> <p id="spar0010">Incidence rate ratios (IRRs) for all, vaccine type, and non-vaccine type IPD were calculated by age-group, using comparable case definitions and time periods post 7vPCV introduction.</p> </sec> <sec> <title id="sect0020">Results</title> <p id="spar0015">At baseline, the % of IPD due to 7vPCV serotypes (VT) disease in children <5 years was 88% in Greater Sydney (GS), 83% in the United States (US), and 74% in England and Wales (E&W). IRR for VT IPD <5 years in GS was 0.05 (0.02–0.09), for ≥65 years was 0.15 (0.12–0.19) and for all ages 0.12 (0.10–0.13). In the US, IRR for VT IPD was lower in each age group, and for all ages the 95% CI of the IRR (0.06 (0.05–0.07)), did not overlap with GS or E&W (0.14 (0.11–0.18)). In contrast, the IRR for IPD due to any serotype did not differ between sites for any age group or overall.</p> </sec> <sec> <title id="sect0025">Conclusions</title> <p id="spar0020">Differences in direct and indirect reductions in VT IPD with a "3 + 0″ 7vPCV schedule versus "2 + 1″ or "3 + 1″ were small. All 3 countries moved to 13vPCV by 2011; data post 13vPCV will be important to assess IPD impact using more similar baseline incidence and comparison periods.</p> </sec> </abstract>