9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors. Issue 14 (15th July 2015)

• Record Type: Journal Article
• Authors: Zimmermann, Kurt; Sang, Xiaopeng; Mastalerz, Harold A.; Johnson, Walter L.; Zhang, Guifen; Liu, Qingjie; Batt, Douglas; Lombardo, Louis J.; Vyas, Dinesh; Trainor, George L.; Tokarski, John S.; Lorenzi, Matthew V.; You, Dan; Gottardis, Marco M.; Lippy, Jonathan; Khan, Javed; Sack, John S.; Purandare, Ashok V.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 14(2015)
• Page Start: 2809
• Page End: 2812
• Publication Date: 2015-07-15
• Subjects: Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.04.101
• Languages: English
• ISSNs: 0960-894X

Abstract

<abstract xml:lang="en" abstract-type="graphical" id="ab005"> <title id="st005">Graphical abstract</title> <sec> <p id="sp0005">The discovery, synthesis, and characterization of 9<italic>H</italic>-carbazole-1-carboxamides as potent and selective ATP-competitive inhibitors of Janus kinase 2 (JAK2) are discussed. <fig id="f0040" position="anchor"><graphic position="anchor" xlink:href="ark:/27927/pgjrz7xmvf" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></fig></p> </sec> </abstract>