Synthesis and antitumor activity of 5-(5-halogenated-2-oxo-1H-pyrrolo[2, 3-b]pyridin-(3Z)-ylidenemethyl)-2, 4-dimethyl-1H-pyrrole-3-carboxamides. Issue 14 (15th July 2015)

• Record Type: Journal Article
• Authors: Wang, Minghua; Ye, Cheng; Liu, Mingliang; Wu, Zhaoyang; Li, Linhu; Wang, Chunlan; Liu, Xiujun; Guo, Huiyuan
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 14(2015)
• Page Start: 2782
• Page End: 2787
• Publication Date: 2015-07-15
• Subjects: Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.05.017
• Languages: English
• ISSNs: 0960-894X

Abstract

<abstract xml:lang="en" abstract-type="graphical" id="ab005"> <title id="st005">Graphical abstract</title> <sec> <p id="sp0005">A series of 5-halogenated-7-azaindolin-2-one derivatives were synthesized. Compound <bold>13c7</bold> were found to be more active than Sunitinib against all of the tested cancer cell lines. <fig id="f0035" position="anchor"><graphic position="anchor" xlink:href="ark:/27927/pgjrz7xfs0" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></fig></p> </sec> </abstract>