CD47 protein expression in acute myeloid leukemia: A tissue microarray-based analysis. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Galli, Serena; Zlobec, Inti; Schürch, Christian; Perren, Aurel; Ochsenbein, Adrian F.; Banz, Yara
• Is Part Of: Leukemia research. Volume 39:Issue 7(2015:Jul.)
• Page Start: 749
• Page End: 756
• Publication Date: 2015-07
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.04.007
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Expression of CD47 on leukemic stems cells inhibits macrophage-mediated phagocytosis.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">We examine CD47 by immunohistochemistry in a bone marrow tissue microarray in AML.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">High CD47 expression correlates with a higher leukemic cell tumor load.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">High CD47 expression in BM blasts does not predict worse clinical outcome.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">A bone marrow AML tissue microarray is feasible to investigate new markers in AML.</p> </list-item> </list> </p> </sec> </abstract>