Hypoxia regulates proliferation of acute myeloid leukemia and sensitivity against chemotherapy. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Drolle, Heidrun; Wagner, Michaela; Vasold, Jochen; Kütt, Alexander; Deniffel, Christian; Sotlar, Karl; Sironi, Silvia; Herold, Tobias; Rieger, Christina; Fiegl, Michael
• Is Part Of: Leukemia research. Volume 39:Issue 7(2015:Jul.)
• Page Start: 779
• Page End: 785
• Publication Date: 2015-07
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.04.019
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Hypoxia is present in the bone marrow but levels are not altered in AML.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">This physiological hypoxia ranges from 1 to 6% O₂.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Hypoxia leads to decreased proliferation and chemosensitivity of AML blasts.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Relevant mechanisms comprise regulation of p27 and antiapoptotic proteins.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">PI3Kinase seems to be involved and inhibition could be therapeutically exploited.</p> </list-item> </list> </p> </sec> </abstract>