IGHV gene usage and mutational status in follicular lymphoma: Correlations with prognosis and patient age. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Berget, Ellen; Molven, Anders; Løkeland, Turid; Helgeland, Lars; Vintermyr, Olav Karsten
• Is Part Of: Leukemia research. Volume 39:Issue 7(2015:Jul.)
• Page Start: 702
• Page End: 708
• Publication Date: 2015-07
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.03.003
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005"> <italic>IGHV</italic>3 subset genes were the most frequently used in follicular lymphoma.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Usage of <italic>IGHV</italic>5 or more than one <italic>IGHV</italic> subgroup was associated with adverse prognosis.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Unmutated <italic>IGHV</italic> genes (showing &gt;98% homology) were found in 15.2% of the cases.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">In contrast to CLL, unmutated <italic>IGHV</italic> genes were not associated with adverse prognosis.</p> </list-item> </list> </p> </sec> </abstract>