Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms. (June 2015)

• Record Type: Journal Article
• Authors: Rochette, Luc; Guenancia, Charles; Gudjoncik, Aurélie; Hachet, Olivier; Zeller, Marianne; Cottin, Yves; Vergely, Catherine
• Is Part Of: Trends in pharmacological sciences. Volume 36:Number 6(2015)
• Page Start: 326
• Page End: 348
• Publication Date: 2015-06
• Subjects: Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2015.03.005
• Languages: English
• ISSNs: 0165-6147

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Anthracyclines and trastuzumab are effective chemotherapies that can cause cardiotoxicity.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Cardiotoxicity is due to a combination of 'on-target' and 'off-target' effects.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Neuregulin-1 in the microvascular endothelium is involved in cardiotoxicity.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">ErbB2 could be a potential target for anticancer therapy.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Heme oxygenase-1 inhibition may be a strategy to enhance the response to chemotherapy.</p> </list-item> <list-item id="lsti0030"> <label></label> <p id="par0030">Notch-1 is a novel target in trastuzumab-resistant breast cancer.</p> </list-item> </list> </p> </sec> </abstract>