Acetylsalicylic acid does not alter thermo-effector responses during mild whole-body passive heat stress in young men. (June 2015)

• Record Type: Journal Article
• Authors: Carter, Stephen J.; Herron, Robert L.; Akers, S. Zeb; Bishop, Phillip A.
• Is Part Of: International journal of hyperthermia. Volume 31:Number 4(2015)
• Page Start: 319
• Page End: 324
• Publication Date: 2015-06
• Subjects: Thermotherapy -- Periodicals; 615.832
• DOI: 10.3109/02656736.2014.999721
• Languages: English
• ISSNs: 0265-6736

Abstract

<abstract> <title>Abstract</title> <p>Acetylsalicylic acid (ASA), aspirin, exerts potent systemic effects that may interfere with normal thermo-effector responses. We investigated the influence of commonly ingested ASA doses on measures of skin blood flow (SkBF) and local sweat rate (SR) during whole-body, passive heat stress. Seven male participants completed counter-balanced trials to compare ASA treatments (single dose 325 mg or 4 consecutive days 81 mg (4-d 81 mg)) to control (no ASA). Laser-Doppler flowmetry provided an index of SkBF. A ventilated capsule measured local sweat rate via capacitance hygrometry. Mean body temperature (<inline-formula><tex-math notation="TeX"><![CDATA[\def\newpage{\vfill \break } \nopagenumbers $ \overline {{\rm T} }_{\rm b} $ \newpage \end]]></tex-math></inline-formula>) was increased by 1 °C above baseline using a water-perfused suit. <inline-formula><tex-math notation="TeX"><![CDATA[\def\newpage{\vfill \break } \nopagenumbers $ \overline {{\rm T} }_{\rm b} $ \newpage \end]]></tex-math></inline-formula> was similar at the onset of cutaneous vasodilation among trials. Cutaneous vascular conductance, expressed as a percentage change from baseline, was not different among trials. Additionally, <inline-formula><tex-math notation="TeX"><![CDATA[\def\newpage{\vfill \break } \nopagenumbers $ \overline {{\rm T} }_{\rm b} $ \newpage \end]]></tex-math></inline-formula> at the onset of local SR and SR sensitivity did not differ among trials. While ASA has previously been shown to influence SkBF during heat stress, it is possible our cohort's relatively young age may have contributed to our dissimilar results.</p> </abstract>