Galectin-3, Carotid Plaque Vulnerability, and Potential Effects of Statin Therapy. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Kadoglou, N.P.E.; Sfyroeras, G.S.; Spathis, A.; Gkekas, C.; Gastounioti, A.; Mantas, G.; Nikita, K.S.; Karakitsos, P.; Liapis, C.D.
• Is Part Of: European journal of vascular and endovascular surgery. Volume 49:Issue 1(2015:Jan.)
• Page Start: 4
• Page End: 9
• Publication Date: 2015-01
• Subjects: Blood-vessels -- Endoscopic surgery -- Periodicals; Blood-vessels -- Surgery -- Periodicals; Vascular Surgical Procedures -- Periodicals; Vascular Surgical Procedures -- methods -- Periodicals; Vaisseaux sanguins -- Chirurgie -- Périodiques; Vaisseaux sanguins -- Chirurgie endoscopique -- Périodiques; Blood-vessels -- Endoscopic surgery; Blood-vessels -- Surgery; Endoscopy; Electronic journals; Periodicals; Electronic journals; 617.413005
• DOI: 10.1016/j.ejvs.2014.10.009
• Languages: English
• ISSNs: 1078-5884

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title id="sectitle0010">Objectives</title> <p id="abspara0010">Galectin-3, a member of galectines, a family of β-galactoside-specific lectins, has been reported to propagate vascular inflammation. The role of galectin-3 in carotid atherosclerosis is controversial. The aim of this study was to investigate the relationship of galectin-3 with plaque vulnerability in patients with high grade carotid stenosis.</p> </sec> <sec> <title id="sectitle0015">Methods</title> <p id="abspara0015">This was a cross sectional study of patients undergoing carotid endarterectomy (CEA). Carotid plaques obtained from 78 consecutive patients (40 symptomatic [SG], 38 asymptomatic [AG]) undergoing CEA were histologically analyzed for galectin-3, macrophages (CD68) and laminin. Pre-operatively the biochemical profile and plaque echogenicity (gray-scale median, GSM) score were determined.</p> </sec> <sec> <title id="sectitle0020">Results</title> <p id="abspara0020">There were no significant differences in clinical and demographic parameters between SG and AG (<italic>p</italic> > .05). The SG had a lower GSM score (44.21 ± 18.24 vs. 68.79 ± 28.79, <italic>p</italic> < .001) and a smaller positive stained area for galectin-3 (4.89 ± 1.60% vs. 12.01 ± 5.91%, <italic>p</italic> < .001) and laminin (0.88 ± 0.71% vs. 3.46 ± 2.12%, <italic>p</italic> < .001) than the AG. On the other hand, intra-plaque macrophage content was increased in SG (<italic>p</italic> < .001). For the whole cohort, symptomatic status was independently associated with intra-plaque contents of both galectin-3 (OR = 0.634, <italic>p</italic> < .001), and GSM score (OR = 0.750, <italic>p</italic> < .001). Notably, patients on long term statin treatment had elevated galectin-3 and lowered macrophage intra-plaque concentrations compared with those on short term treatment (<italic>p</italic> < .05).</p> </sec> <sec> <title id="sectitle0025">Conclusions</title> <p id="abspara0025">A low galectin-3 intra-plaque concentration seems to correlate with clinically and ultrasonically defined unstable human carotid plaques. Long term statin treatment may induce increase of intra-plaque galectin-3 concentration mediating plaque stabilization.</p> </sec> </abstract>