Grass carp SARM1 and its two splice variants negatively regulate IFN-I response and promote cell death upon GCRV infection at different subcellular locations. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Yan, Nana; Su, Jianguo; Yang, Chunrong; Rao, Youliang; Feng, Xiaoli; Wan, Quanyuan; Lei, Chuzhao
• Is Part Of: Developmental and comparative immunology. Volume 48:Issue 1(2015)
• Page Start: 102
• Page End: 115
• Publication Date: 2015-01
• Subjects: Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2014.09.009
• Languages: English
• ISSNs: 0145-305X

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Two novel splice variants CiSARM1s1 and CiSARM1s2 only retain ARM domain(s).</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">CiSARM1 and CiSARM1s1 are located in mitochondria, while CiSARM1s2 resides in the whole cell.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">CiSARM1 inhibits GCRV-triggered IFN-I response by affecting the molecules in TRIF-, MyD88- and IPS-1-dependent pathways.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">CiSARM1s1 and CiSARM1s2 inhibit GCRV-triggered IFN-I response by suppressing mediators in MyD88 and IPS-1signal pathways.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">CiSARM1, CiSARM1s1 and CiSARM1s2 promote GCRV-induced cell death.</p> </list-item> </list> </p> </sec> </abstract>