Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Baert, Kim; Sonck, Eva; Goddeeris, Bruno M.; Devriendt, Bert; Cox, Eric
• Is Part Of: Developmental and comparative immunology. Volume 48:Issue 1(2015)
• Page Start: 192
• Page End: 203
• Publication Date: 2015-01
• Subjects: Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2014.10.005
• Languages: English
• ISSNs: 0145-305X

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">We explored the contribution of CR3 and dectin-1 in β-glucan recognition in pigs.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">As in humans, CR3 is the most important β-glucan receptor in porcine neutrophils.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Macrophages utilise a more diverse receptor to recognise β-glucans.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Focal adhesion kinase acts as a master switch regulating β-glucan-mediated responses.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">We discuss these findings in comparison with β-glucan receptors in mice and man.</p> </list-item> </list> </p> </sec> </abstract>