CpA/CpG methylation of CiMDA5 possesses tight association with the resistance against GCRV and negatively regulates mRNA expression in grass carp, Ctenopharyngodon idella. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Shang, Xueying; Su, Jianguo; Wan, Quanyuan; Su, Juanjuan
• Is Part Of: Developmental and comparative immunology. Volume 48:Issue 1(2015)
• Page Start: 86
• Page End: 94
• Publication Date: 2015-01
• Subjects: Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2014.09.007
• Languages: English
• ISSNs: 0145-305X

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">There are methylated CpA loci in CGIs located in the first exon of <italic>CiMDA5</italic>.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Methylation levels were extremely higher in the susceptible group at four CpA/CpG loci.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020"> <italic>CiMDA5</italic> expression was negatively regulated by DNA methylation.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Four significant CpA/CpG loci consisted of a densely methylated element (DME).</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">Most of the CpA/CpG loci were unmethylated in CGIs.</p> </list-item> </list> </p> </sec> </abstract>