Generic GPCR residue numbers – aligning topology maps while minding the gaps. (January 2015)

• Record Type: Journal Article
• Authors: Isberg, Vignir; de Graaf, Chris; Bortolato, Andrea; Cherezov, Vadim; Katritch, Vsevolod; Marshall, Fiona H.; Mordalski, Stefan; Pin, Jean-Philippe; Stevens, Raymond C.; Vriend, Gerrit; Gloriam, David E.
• Is Part Of: Trends in pharmacological sciences. Volume 36:Number 1(2015)
• Page Start: 22
• Page End: 31
• Publication Date: 2015-01
• Subjects: Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2014.11.001
• Languages: English
• ISSNs: 0165-6147

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Generic residue numbering for GPCR classes A, B, C, and F is reviewed.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">A new complementary structure-based numbering system is proposed that accounts for helix bulges and constrictions.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Illustrative examples of cross-class and structure-based numbering are presented.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">GPCRDB web tools to number any receptor sequence or structure are summarized.</p> </list-item> </list> </p> </sec> </abstract>