Sterigmatocystin-induced oxidative DNA damage in human liver-derived cell line through lysosomal damage. Issue 1 (February 2015)

• Record Type: Journal Article
• Authors: Gao, Wei; Jiang, Liping; Ge, Lan; Chen, Min; Geng, Chengyan; Yang, Guang; Li, Qiujuan; Ji, Fang; Yan, Qiu; Zou, Yang; Zhong, Laifu; Liu, Xiaofang
• Is Part Of: Toxicology in vitro. Volume 29:Issue 1(2015)
• Page Start: 1
• Page End: 7
• Publication Date: 2015-02
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.08.007
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st120">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0145">Sterigmatocystin (STC) exerts genotoxic effects on HepG2 cells.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0150">Lysosomal leakage is likely to be an important event of STC-induced DNA damage.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0155">STC-induced DNA strand breaks could be mediated by oxidative stress.</p> </list-item> </list> </p> </sec> </abstract>