Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo. Issue 1 (February 2015)

• Record Type: Journal Article
• Authors: Niu, Xiaoyu; de Graaf, Inge A.M.; van de Vegte, Dennis; Langelaar-Makkinje, Miriam; Sekine, Shuichi; Groothuis, Geny M.M.
• Is Part Of: Toxicology in vitro. Volume 29:Issue 1(2015)
• Page Start: 168
• Page End: 175
• Publication Date: 2015-02
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.10.004
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st105">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0210">Mrp2 deficient rat intestine <italic>ex vivo</italic> is intrinsically less sensitive to diclofenac toxicity.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0215">Lower uptake of diclofenac contributes to the lower diclofenac toxicity in Mrp2⁻ rat intestine.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0220">Adaptive changes in metabolism and transport in Mrp2⁻ rats are different between liver and intestine.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0225">Precision cut intestinal slices allow studying drug-induced toxicity in the gut without interference of liver.</p> </list-item> </list> </p> </sec> </abstract>