Epigenetic marks responsible for cadmium-induced melanoma cell overgrowth. Issue 1 (February 2015)

• Record Type: Journal Article
• Authors: Venza, Mario; Visalli, Maria; Biondo, Carmelo; Oteri, Rosaria; Agliano, Federica; Morabito, Silvia; Teti, Diana; Venza, Isabella
• Is Part Of: Toxicology in vitro. Volume 29:Issue 1(2015)
• Page Start: 242
• Page End: 250
• Publication Date: 2015-02
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.10.020
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st120">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0120">Cd pollution promotes <italic>p16^INK4A</italic> hypermethylation and inactivation in uveal melanoma cell lines.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0125">Cd exposure is able to determine <italic>caspase 8</italic> promoter methylation and silencing in cutaneous melanoma cell lines.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0130">DNMT3a appears to be required for <italic>p16^INK4A</italic> methylation and DNMT1 seems to play a significant role in <italic>caspase 8</italic> methylation.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0135">Ectopic expression of <italic>p16^INK4A</italic> reverts the overgrowth in response to Cd.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0140">Overexpression of <italic>caspase 8</italic> prevents the decrease in the apoptosis rate induced by Cd.</p> </list-item> </list> </p> </sec> </abstract>