ABCB1 and ABCC4 efflux transporters are involved in methyl parathion detoxification in ZFL cells. Issue 1 (February 2015)

• Record Type: Journal Article
• Authors: Nornberg, Bruna Félix; Batista, Carolina Reyes; Almeida, Daniela Volcan; Trindade, Gilma Santos; Marins, Luis Fernando
• Is Part Of: Toxicology in vitro. Volume 29:Issue 1(2015)
• Page Start: 204
• Page End: 210
• Publication Date: 2015-02
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.09.010
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st075">Highlights</title> <sec> <p id="sp0040"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0135">The MXR mechanism is activated to detoxify from methyl parathion.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0140">The toxic effects of MP on ZFL cells were increased in the presence of the efflux transporter inhibitor.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0155">The combined exposure to MP and the inhibitor caused an increase in gene expression of P-gp1 (Abcb1) and MRP4 (Abcc4).</p> </list-item> </list> </p> </sec> </abstract>