Validation of murine and human placental explant cultures for use in sex steroid and phase II conjugation toxicology studies. Issue 1 (February 2015)

• Record Type: Journal Article
• Authors: Sato, Brittany L.; Ward, Monika A.; Astern, Joshua M.; Kendal-Wright, Claire E.; Collier, Abby C.
• Is Part Of: Toxicology in vitro. Volume 29:Issue 1(2015)
• Page Start: 103
• Page End: 112
• Publication Date: 2015-02
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.09.008
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab015"> <title id="st150">Highlights</title> <sec> <p id="sp0045"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0220">Human placental explants are validated for cytokine but not sex steroid studies.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0225">Mouse placental explant cultures have not previously been examined.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0230">We assessed <italic>ex vivo</italic> culture of both species for steroidogenic and clearance traits.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0235">Human explants may be used for metabolism and clearance, but not endocrine studies.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0240">Mouse explants may be used for steroidogenesis, but not phase II metabolism studies.</p> </list-item> </list> </p> </sec> </abstract>