Contribution of the immune system to bystander and non-targeted effects of ionizing radiation. Issue 1 (1st January 2015)

• Record Type: Journal Article
• Authors: Rödel, Franz; Frey, Benjamin; Multhoff, Gabriele; Gaipl, Udo
• Is Part Of: Cancer letters. Volume 356:Issue 1(2015)
• Page Start: 105
• Page End: 113
• Publication Date: 2015-01-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2013.09.015
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab905"> <title id="st115">Highlights</title> <sec> <p id="sp9005"> <list id="l7005"> <list-item id="o6005"> <label></label> <p id="p0165">X-irradiation displays anti-inflammatory activities if applied at low (&lt; 1 Gy) doses.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0170">Pro-inflammatory effects and modulation of anti-tumour immune responses dominate at doses &gt;2 Gy.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0175">Immune modulatory effects originate from nuclear damage and non-(DNA) targeted mechanisms.</p> </list-item> <list-item id="o9015"> <label></label> <p id="p9175">Abscopal effects of local X-irradiation are mediated by the induction of immunogenic forms of cell death.</p> </list-item> <list-item id="o8015"> <label></label> <p id="p8175">HSP70 immunotherapy may increases therapeutic effectiveness of (chemo) radiotherapy.</p> </list-item> </list> </p> </sec> </abstract>