3-O-sulfo-β-d-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Phongsisay, Vongsavanh; Iizasa, Ei'ichi; Hara, Hiromitsu; Yamasaki, Sho
• Is Part Of: Molecular immunology. Volume 63:Issue 2(2015:Feb.)
• Page Start: 595
• Page End: 599
• Publication Date: 2015-02
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2014.07.023
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">3-<italic>O</italic>-sulfo-β-<sc>d</sc>-galactosylceramide C24:1 (C24:1) is an endogenous sulfoglycolipid.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">LMIR5 interacts preferentially with C24:1 among various brain glycolipids examined.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">C24:1-induced MCP1 production is reduced in the absence of adaptor protein DAP12.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">C24:1 activates transcriptional factor NFAT through DAP12-coupled LMIR5.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">LMIR5 recognizes the 3-<italic>O</italic>-sulfo-β-<sc>d</sc>-galactose moiety.</p> </list-item> </list> </p> </sec> </abstract>