SIGNR1-mediated phagocytosis, but not SIGNR1-mediated endocytosis or cell adhesion, suppresses LPS-induced secretion of IL-6 from murine macrophages. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Kawauchi, Yoko; Takagi, Hideaki; Hanafusa, Kei; Kono, Mirei; Yamatani, Minami; Kojima, Naoya
• Is Part Of: Cytokine. Volume 71:Issue 1(2015)
• Page Start: 45
• Page End: 53
• Publication Date: 2015-01
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2014.08.002
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st080">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0140">LPS-induced secretion of IL-6 but not TNF-α is suppressed by SIGNR1-mediated phagocytosis.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0145">LPS-induced IL-6 secretion is not suppressed by SIGNR1-mediated endocytosis or cell adhesion.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0150">Phagocytosis do not interfere with IL-6 mRNA transcription, but affects IL-6 mRNA stability.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0155">A PI3 kinase inhibitor blocks the suppression of IL-6 secretion by SIGNR1-mediated phagocytosis.</p> </list-item> </list> </p> </sec> </abstract>