Molecular basis of mast cell disease. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Soucie, Erinn; Brenet, Fabienne; Dubreuil, Patrice
• Is Part Of: Molecular immunology. Volume 63:Issue 1(2015:Jan.)
• Page Start: 55
• Page End: 60
• Publication Date: 2015-01
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2014.03.013
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Recurrent somatic mutations have been identified in mastocytosis patients.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Distinct KIT mutants are associated with specific classes of mast cell disease.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Epigenetic and splicing factor mutations are associated with aggressive mastocytosis.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Epigenetic and splicing mutations occur early in disease ontology.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">SRSF2, TET2 and KITD816V mutations frequently occur together in patients.</p> </list-item> </list> </p> </sec> </abstract>