Cover Picture: A Cactus‐Derived Toxin‐Like Cystine Knot Peptide with Selective Antimicrobial Activity (ChemBioChem 7/2015). Issue 7 (4th May 2015)

• Record Type: Journal Article
• Authors: Aboye, Teshome L.; Strömstedt, Adam A.; Gunasekera, Sunithi; Bruhn, Jan G.; El‐Seedi, Hesham; Rosengren, K. Johan; Göransson, Ulf
• Is Part Of: Chembiochem. Volume 16:Issue 7(2015)
• Page Start: 1013
• Page End: 1013
• Publication Date: 2015-05-04
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201590015
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The cover picture shows</bold> the solution structure of the peptide Ep‐AMP1 and the source of the peptide, the San Pedro cactus (<italic>Echinopsis pachanoi</italic>). Ep‐AMP1 is the first cystine knot peptide isolated from the plant family of Cactaceae. Sequence homology places this peptide in the family of C6‐type of antimicrobial peptides, but the three dimensional structure is highly similar to that of a peptide‐based spider neurotoxin. Ep‐AMP1 displays potent antimicrobial and membrane permeabilising activity. The article by U. Göransson et al. (see the full paper on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 1068 ff.</ext-link>) reports the discovery, sequencing, chemical synthesis, structure determination and bioactivity of this peptide. Photo of <italic>E. pachanoi</italic> by Matthias Uhlig, Uhlig Kakteen.<graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjjv0p5sw" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>