Copper‐Catalyzed Intermolecular Carboetherification of Unactivated Alkenes by Alkyl Nitriles and Alcohols1. (3rd March 2015)

• Record Type: Journal Article
• Authors: Chatalova‐Sazepin, Claire; Wang, Qian; Sammis, Glenn M.; Zhu, Jieping
• Is Part Of: Angewandte Chemie. Volume 127:Number 18(2015)
• Page Start: 5533
• Page End: 5536
• Publication Date: 2015-03-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201412357
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A three‐component carboetherification of unactivated alkenes has been developed allowing the rapid building of complexity from simple starting materials. A wide range of α‐substituted styrenes underwent smooth reactions with unactivated alkyl nitriles and alcohols to afford γ‐alkoxy alkyl nitriles with concomitant generation of a quaternary carbon center. A radical clock experiment provided clear‐cut evidence that the reaction proceeds through a tertiary alkyl radical intermediate.</p> </abstract>