Cover Picture: Intracellular Modulation of Excited‐State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells (Angew. Chem. Int. Ed. 18/2015). Issue 18 (27th March 2015)

• Record Type: Journal Article
• Authors: Kolemen, Safacan; Işık, Murat; Kim, Gyoung Mi; Kim, Dabin; Geng, Hao; Buyuktemiz, Muhammed; Karatas, Tugce; Zhang, Xian‐Fu; Dede, Yavuz; Yoon, Juyoung; Akkaya, Engin U.
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 18(2015)
• Page Start: 5263
• Page End: 5263
• Publication Date: 2015-03-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201502270
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic> <bold>Orthogonal BODIPY dimers</bold> </italic> offer exciting potential as activatable photosensitizers for photodynamic therapy. In their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 5340 ff., </ext-link> J. Yoon, E. U. Akkaya et al. report a photosensitizer that is switched on by a reaction with glutathione (GSH). Comparative cell culture data show that the agent is preferentially activated in cancer cells as they feature a higher glutathione level than normal cells.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjjm8x2x9" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>