Genetic polymorphisms in the prostaglandin pathway genes and risk of head and neck cancer. (28th April 2014)

• Record Type: Journal Article
• Authors: Lee, W‐T; Huang, C‐C; Chen, K‐C; Wong, T‐Y; Ou, C‐Y; Tsai, S‐T; Yen, C‐J; Fang, S‐Y; Lo, H‐I; Wu, Y‐H; Hsueh, W‐T; Yang, M‐W; Lin, F‐C; Hsiao, J‐R; Huang, J‐S; Chang, J‐Y; Chang, K‐Y; Wu, S‐Y; Lin, C‐L; Wang, Y‐H; Weng, Y‐L; Yang, H‐C; Chang, JS
• Is Part Of: Oral diseases. Volume 21:Number 2(2015:Mar.)
• Page Start: 207
• Page End: 215
• Publication Date: 2014-04-28
• Subjects: Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12244
• Languages: English
• ISSNs: 1354-523X

Abstract

<abstract abstract-type="main" id="odi12244-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="odi12244-sec-0001" sec-type="section"> <title>Objective</title> <p>Previous studies examining the association between genetic variations in prostaglandin pathway and risk of head and neck cancer (HNC) have only included polymorphisms in the <italic>PTGS2</italic> (<italic>COX2</italic>) gene. This study investigated the association between genetic polymorphisms of six prostaglandin pathway genes (<italic>PGDS, PTGDS, PTGES, PTGIS, PTGS1</italic> and <italic>PTGS2</italic>), and risk of HNC.</p> </sec> <sec id="odi12244-sec-0002" sec-type="section"> <title>Methods</title> <p>Interviews regarding the consumption of alcohol, betel quid, and cigarette were conducted with 222 HNC cases and 214 controls. Genotyping was performed for 48 tag and functional single‐nucleotide polymorphisms (SNPs).</p> </sec> <sec id="odi12244-sec-0003" sec-type="section"> <title>Results</title> <p>Two tag SNPs of <italic>PTGIS</italic> showed a significant association with HNC risk [rs522962: log‐additive odds ratio (OR) = 1.42, 95% confidence interval (CI): 1.01–1.99 and dominant OR = 1.58, 95% CI: 1.02–2.47; rs6125671: log‐additive OR = 1.49, 95% CI: 1.08–2.05 and dominant OR = 1.96, 95% CI: 1.16–3.32]. In addition, a region in <italic>PTGIS</italic> tagged by rs927068 and rs6019902 was significantly associated with risk of HNC (global <italic>P </italic>=<italic> </italic>0.007). Finally, several SNPs interacted with betel quid and cigarette to influence the risk of HNC.</p> </sec> <sec id="odi12244-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Genetic variations in prostaglandin pathway genes are associated with risk of HNC and may modify the relationship between use of betel quid or cigarette and development of HNC.</p> </sec> </abstract>