Arginine promotes fluoride uptake into artificial carious lesions in vitro. (March 2015)

• Record Type: Journal Article
• Authors: Cheng, X; Xu, P; Zhou, X; Deng, M; Cheng, L; Li, M; Li, Y; Xu, X
• Is Part Of: Australian dental journal. Volume 60:Number 1(2015:Mar.)
• Page Start: 104
• Page End: 111
• Publication Date: 2015-03
• Subjects: Dentistry -- Periodicals; Dentistry -- Periodicals; Dentisterie -- Australie -- Périodiques; Tandheelkunde; 617.6
• DOI: 10.1111/adj.12278
• Languages: English
• ISSNs: 0045-0421

Abstract

<abstract abstract-type="main" id="adj12278-abs-0001"> <title>Abstract</title> <sec id="adj12278-sec-0001" sec-type="section"> <title>Background</title> <p>This study focused on the interaction of arginine and fluoride on the remineralization of artificial enamel carious lesions <italic>in vitro</italic>.</p> </sec> <sec id="adj12278-sec-0002" sec-type="section"> <title>Methods</title> <p>Human enamel blocks with artificial carious lesions were prepared and randomly divided into six treatment groups (n = 30 for each group): deionized water, arginine solution, NaF solution, arginine/NaF solution, arginine‐free fluoride toothpaste slurry and arginine‐containing fluoride toothpaste slurry. After a pH‐cycling regimen for 10 days, subsets of specimens from each group were subjected to independent analysis, including surface microhardness (n = 8/30), cross‐sectional microhardness (n = 8/30), enamel fluoride uptake (n = 8/30) and polarized light microscopy (n = 6/30). The samples tested for surface microhardness were further subjected to simulated plaque acid challenge before surface microhardness was remeasured.</p> </sec> <sec id="adj12278-sec-0003" sec-type="section"> <title>Results</title> <p>Arginine solution promoted remineralization compared with deionized water control (p < 0.05). When used in combination with fluoride, arginine significantly increased fluoride uptake compared with fluoride alone (p < 0.05). In addition, lesions treated with arginine‐containing toothpaste also showed superior fluoride uptake compared with those treated with conventional fluoride toothpaste (p < 0.05).</p> </sec> <sec id="adj12278-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Arginine promoted enamel fluoride uptake when used in combination with fluoride, thereby contributing to resistance of enamel to carious demineralization.</p> </sec> </abstract>