Exploring hypertension genome‐wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics. (6th February 2015)

• Record Type: Journal Article
• Authors: Cabrera, Claudia P; Ng, Fu Liang; Warren, Helen R; Barnes, Michael R; Munroe, Patricia B; Caulfield, Mark J
• Is Part Of: Wiley interdisciplinary reviews. Volume 7:Number 2(2015)
• Page Start: 73
• Page End: 90
• Publication Date: 2015-02-06
• Subjects: Systems biology -- Periodicals; Medicine -- Periodicals; 610
• DOI: 10.1002/wsbm.1290
• Languages: English
• ISSNs: 1939-5094

Abstract

<abstract abstract-type="main" id="wsbm1290-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="wsbm1290-para-0001">Hypertension is a major risk factor for global mortality. Recent genome‐wide association studies (GWAS) have led to successful identification of many genetic loci influencing blood pressure, although these studies account for less than 5% of heritability. While genetic discovery efforts continue, it is timely to pause and reflect on what information has been gained to date from reported loci. Knowledge from GWAS findings inform our understanding of the pathways and pleiotropy underpinning hypertension and aid in the identification of potential druggable targets. By reviewing blood pressure loci we aim to determine how much potential the current observations have for future clinical utility. <italic>WIREs Syst Biol Med</italic> 2015, 7:73–90. doi: 10.1002/wsbm.1290</p> <p>For further resources related to this article, please visit the <ext-link ext-link-type="uri" xlink:href="http://wires.wiley.com/remdoi.cgi?doi=10.1002/wsbm.1290" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">WIREs website</ext-link>.</p> <p>Conflict of interest: The authors have declared no conflicts of interest for this article.</p> </abstract>