Turning peptides in comb silicone polymers§. (16th February 2015)

• Record Type: Journal Article
• Authors: Jebors, Said; Pinese, Coline; Nottelet, Benjamin; Parra, Karine; Amblard, Muriel; Mehdi, Ahmad; Martinez, Jean; Subra, Gilles
• Is Part Of: Journal of peptide science. Volume 21:Number 3(2015:Mar.)
• Page Start: 243
• Page End: 247
• Publication Date: 2015-02-16
• Subjects: Peptides -- Periodicals; Peptides -- Periodicals; 572.65
• DOI: 10.1002/psc.2757
• Languages: English
• ISSNs: 1075-2617

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We have recently reported on a new class of silicone–peptide‵ biopolymers obtained by polymerization of di‐functionalized chlorodimethylsilyl hybrid peptides. Herein, we describe a related strategy based on dichloromethylsilane‐derived peptides, which yield novel polymers with a polysiloxane backbone, comparable with a silicone‐bearing pendent peptide chains. Interestingly, polymerization is chemoselective toward amino acids side‐chains and proceeds in a single step in very mild conditions (neutral pH, water, and room temperature). As potential application, a cationic sequence was polymerized and used for antibacterial coating. Copyright © 2015 European Peptide Society and John Wiley &amp; Sons, Ltd.</p> </abstract>