Clinical and molecular epidemiology of neonatal leukemia in Brazil. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Moura, Suellen Valadares; Andrade, Francianne; Magalhães, Isis Q.; Costa, Imaruí; Silva, Denise Bousfield; D'Andrea, Maria Lydia; Pinheiro, Vitória P.; Lee, Maria Lucia M.; Werneck, Fernando; Emerenciano, Mariana; Pombo-de-Oliveira, Maria S.
• Is Part Of: Leukemia & lymphoma. Volume 56:Issue 4(2015:Apr.)
• Page Start: 903
• Page End: 909
• Publication Date: 2015-04
• Subjects: Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.3109/10428194.2014.938327
• Languages: English
• ISSNs: 1042-8194

Abstract

<abstract> <title>Abstract</title> <p>The clinical and molecular findings of 77 cases of neonatal leukemia (NL) and 380 of infant leukemia (IL) were selected to distinguish features between NL and IL. Somatic gene mutations associated with acute leukemia including <italic>FLT3, RAS</italic> and <italic>PTPN11</italic> were revisited. There were 42 cases of congenital leukemia associated with Down syndrome (DS) and 39 of these cases presented features of acute myeloid leukemia (AML)-M7. Twenty-seven of the DS cases underwent spontaneous remission and were reclassified as a transient myeloproliferative disorder. <italic>GATA1</italic> mutations were found in 70% of these cases. In non-DS, frequent abnormalities were <italic>MLL</italic> rearrangements, mainly <italic>MLL–AFF1</italic> in acute lymphoblastic leukemia and <italic>MLL–MLLT3</italic> in AML. The <italic>FLT3</italic> mutation was not found, while <italic>RAS</italic> (<italic>n</italic> = 4) and <italic>PTPN11</italic> (<italic>n</italic> = 2) mutations were identified and reported for the first time in NL. There was substantial evidence to support that somatic abnormalities occur <italic>in utero</italic>. Thus, congenital leukemia is a good model for understanding leukemogenesis.</p> </abstract>