CCAAT/enhancer binding protein α (C/EBPα)+ M2 macrophages contribute to fibrosis in IgG4-related disease?. Issue 3 (May 2015)

• Record Type: Journal Article
• Authors: Yamamoto, Motohisa; Shimizu, Yui; Takahashi, Hiroki; Yajima, Hidetaka; Yokoyama, Yoshihiro; Ishigami, Keisuke; Tabeya, Tetsuya; Suzuki, Chisako; Matsui, Mikiko; Naishiro, Yasuyoshi; Imai, Kohzon; Shinomura, Yasuhisa
• Is Part Of: Modern rheumatology. Volume 25:Issue 3(2015)
• Page Start: 484
• Page End: 486
• Publication Date: 2015-05
• Subjects: Rheumatology -- Periodicals; 616.723005
• DOI: 10.3109/14397595.2014.950826
• Languages: English
• ISSNs: 1439-7595

Abstract

<abstract> <title>Abstract</title> <p>IgG4-related disease (IgG4-RD) is a new disease entity characterized by type 2 helper T (Th2)-dominant inflammation and progressive fibrosis. We found the infiltration of strange cell populations in the fibrotic lesions of submandibular gland specimens obtained from 15 patients with IgG4-RD. These cells expressed CCAAT/enhancer binding protein a (C/EBPα). Many of the cell populations were identified with M2 macrophages. The degrees of infiltration of C/EBPα⁺M2 macrophages and the ratio of fibrotic lesions in the specimens were correlated (r² = 0.83, p &lt; 0.01). We also analyzed the expression of C/EBPα in other chronic inflammatory disorders: synovium in rheumatoid arthritis (RA), liver tissue in chronic viral hepatitis, and mucosa in ulcerative colitis. The specimens from RA and chronic viral hepatitis showed infiltration of C/EBPα⁺ cells, but there were few C/EBPα-positive cells in ulcerative colitis. Fibrosis is not a major issue in ulcerative colitis. In conclusion, we found the remarkable infiltration of C/EBPα⁺M2 macrophages in cases of chronic inflammation with fibrosis, including IgG4-RD. This primitive study also disclosed that most of C/EBPα⁺M2 macrophages localized in fibrotic lesions, and the degree of the infiltration and the ratio of fibrotic area were correlated.</p> </abstract>