Luteal-long GnRH agonist versus flexible-multidose GnRH antagonist protocols for overweight and obese patients who underwent ICSI. (April 2015) - Esinler, I.
Abstract A total of 413 consecutive infertile patients (572 cycles) with a body mass index (BMI) of ≥ 25 kg/m2 were enrolled into the study. The luteal-long GnRH agonist group (Group I) constituted 211 patients (300 cycles) and the flexible-multidose GnRH antagonist group (Group II) constituted 202 patients (272 cycles). The duration of stimulation (d) (10.1 ± 2.5 vs 9.2 ± 2.0; p < 0.01); the total dose of gonadotrophin used (IU) (3, 099.4 ± 2, 885.0 vs 2, 684.0 ± 1, 046.4; p < 0.05) and the E2 level on the day of hCG (pg/ml) (2, 375.8 ± 1, 554.6 vs 1, 905.6 ± 1, 598.8; p < 0.01) were significantly lower in Group II when compared with Group I. However, the ongoing pregnancy per embryo transfer (37.0% vs 25.7%; p < 0.05) and the implantation rate (25.7% vs 15.6%; p < 0.01) were significantly lower in Group II when compared with Group I. In conclusion, we noted that the luteal-long GnRH agonist protocol produced higher implantation rates and higher clinical-ongoing pregnancy rates in overweight and obese patients when compared with the flexible-multidose GnRH antagonist protocol.