Increased plasma monocyte chemoattractant protein-1 levels in patients with isolated low high-density lipoprotein cholesterol. (July 2015)

• Record Type: Journal Article
• Authors: Karabacak, Mustafa; Kahraman, Fatih; Sert, Mehmet; Celik, Erdal; Adali, Mehmet Koray; Varol, Ercan
• Is Part Of: Scandinavian journal of clinical & laboratory investigation. Volume 75:Number 4(2015)
• Page Start: 327
• Page End: 332
• Publication Date: 2015-07
• Subjects: Clinical biochemistry -- Periodicals; Physiology, Pathological -- Periodicals; Physiology, Experimental -- Periodicals; Medicine -- Research -- Periodicals; Clinical medicine -- Periodicals; 616.0072
• DOI: 10.3109/00365513.2014.1003595
• Languages: English
• ISSNs: 0036-5513

Abstract

<abstract> <title>Abstract</title> <p> <bold> <italic>Background</italic>.</bold> High-density lipoprotein cholesterol (HDL-C) inhibits inflammation associated with the development of atherosclerotic plaques. Monocyte chemoattractant protein-1 (MCP-1) contributes to the pathogenesis of atherosclerosis. The aim of this study was to evaluate the relationship between plasma MCP-1 levels and low HDL-C levels in patients without cardiovascular disease (CVD). <bold><italic>Methods</italic>.</bold> This study included 55 patients with low HDL-C (≤ 35 mg/dL) and 33 age- and sex-matched control subjects with normal HDL-C (˃ 35 mg/dL). In addition to MCP-1 levels, laboratory parameters associated with inflammation such as neutrophil-lymphocyte ratio (NLR), uric acid and high sensitivity C-reactive protein (hs-CRP) were also evaluated. <bold><italic>Results</italic>.</bold> HDL-C levels was significantly lower in study group compared to that of the control group (<italic>p</italic> &lt; 0.001). MCP-1 were prominently higher in the low HDL-C group compared with those of the control group (<italic>p</italic> &lt; 0.01). NLR, uric acid and hs-CRP levels were also higher in patients with low HDL-C than controls. <bold><italic>Conclusion</italic>.</bold> These findings suggest that elevated plasma MCP-1 levels and inflammation status might be associated with the increased cardiovascular risk in patients with low HDL-C.</p> </abstract>