Expression of costimulatory molecule B7-H3 and its prognostic implications in human acute leukemia. Issue 4 (May 2015)

• Record Type: Journal Article
• Authors: Hu, Yixin; Lv, Xin; Wu, Yujie; Xu, Ji; Wang, Lingling; Chen, Weifeng; Zhang, Wei; Li, Jianyong; Zhang, Sujiang; Qiu, Hongxia
• Is Part Of: Hematology. Volume 20:Issue 4(2015)
• Page Start: 187
• Page End: 195
• Publication Date: 2015-05
• Subjects: Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; 616.15005
• DOI: 10.1179/1607845414Y.0000000186
• Languages: German
• ISSNs: 1024-5332

Abstract

<abstract> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <sec> <title>Objectives</title> <p>This study focused on the expression pattern and clinical significance of B7-H3 expression in human acute leukemia.</p> </sec> <sec> <title>Methods</title> <p>We systematically analyzed 134 patients with acute myeloid leukemia (101 cases) and acute lymphocytic leukemia (33 cases) by flow cytometry.</p> </sec> <sec> <title>Results</title> <p>The frequency of B7-H3⁺ cases was 44.8% in total. The B7-H3 expression rate differed from 0% to 74.8% in individual cases. The correlation between B7-H3 expression and traditional prognostic factors, such as age and gender, the white blood cell count was not confirmed. However, B7-H3 had a significant higher expression in CD34⁺ cases and high risk karyotypes.</p> </sec> <sec> <title>Conclusions</title> <p>Owing to the expression of B7-H3 being statistically relevant in predicting disease progression and a shorter life survival, our results demonstrated that B7-H3 expression in acute leukemia predicts an unfavorable outcome.</p> </sec> </abstract>